Viraday

Viraday consists of three molecules combined in a fixed-dose combination for managing HIV-1 infection in adults. The molecules include tenofovir disoproxil (TDF) 300 mg, Efavirenz (EFV) 600 mg, and Emtricitabine (FTC) 200 mg. In terms of dosage, the triple-combination drug is taken orally as a single tablet once daily without food. The bedtime dosing schedule is preferred over others, as it eliminates out possibility of procuring symptoms of the nervous system.

Viraday (TDF 300 mg + EFV 600 mg + FTC 200 mg) is avoided in patients with moderate to severe renal (kidney) impairment. It is indicated as a complete regimen for preventing the multiplication of HIV cells in the body. However, it does not necessarily cure the infection.

Initial testing before starting Viraday (TDF 300 mg + EFV 600 mg + FTC 200 mg):

• •  Hepatitis B viral (HBV) infection testing

• •  Chronic kidney disease testing

• •  Testing to determine the functioning of the liver

• •  Pregnancy testing in patients with child-bearing potential or their associated partners

Side-effects and Warnings of Viraday (TDF 300 mg + EFV 600 mg + FTC 200 mg):

Serious side-effects:

• •  Lactic acidosis (High amount of lactic acid in the blood)

• •  Hepatomegaly (Enlarged liver)

• •  Steatosis (Excessive fats in the liver)

• •  Recurrence of HBV infection

• •  Psychiatric side-effects like depression, unusual thoughts, angry behavior, suicidal tendencies, anxiety, aggressive behavior, delusions and psychosis-like symptoms

• •  Thinning of bones (Decreased bone mineral density)

Common side-effects: These side-effects can be reduced after a few weeks of therapy

• •  Headache

• •  Rashes

• •  Dizziness

• •  Difficult in sleeping and concentrating

• •  Infrequent dreams

• •  Tiredness

• •  Gas

• •  Upset stomach

• •  Vomiting

• •  Diarrhea

Other possible side-effects:

• •  Increased amounts of fat in the upper back, neck, breast, and trunk regions

• •  Skin discoloration with small freckles and spots

• •  Inflammation from previous infections

• •  Inflammation of the pancreas

• •  Swelling of the face, lips, tongue or throat due to an allergic reaction to drugs

• •  Shortness of breath

• •  Stomach pain

• •  Indigestion

• •  Weakness

Note: These are not all side effects of Viraday (TDF 300 mg + EFV 600 mg + FTC 200 mg). If you need more information, please consult your doctor.

Warnings and Precautions:

There are certain complications wherein either Viraday (TDF 300 mg + EFV 600 mg + FTC 200 mg) needs to be stopped or used cautiously. These complications have been mentioned in the table below along with their causes.

Complications

Causes

Allergic skin reactions (hypersensitivity)

EFV in the drug combination

Body fat leads to long-term problems

Prescribed, non-prescribed drugs and supplements

Kidney dysfunctions

Nephrotoxic drugs

Pregnancy

The drug itself may cause harm to the fetus