Qurled

Qurled 400 mg (Sofosbuvir) is an anti-viral drug indicated against chronic hepatitis C (HCV) infection with genotype 1-4. Sofosbuvir is known for its direct-acting antiviral (DAA) properties, inhibiting non-structural protein 5B (NS5B) protein, a special type of protein responsible for multiplication (RNA replication and virion assembly) of viral cells.

For achieving a sustained virologic response (SVR), sofosbuvir is used with other anti-HCV agents assisting in,

• •  Reduction of damages associated with liver

• •  Improvement in the quality of life of patients

• •  Liver cancer incidence

Administration of Qurled 400 mg (Sofosbuvir):

Qurled 400 mg (Sofosbuvir) is administered orally once in a form of 400 mg dose taken with or without food. In addition, either ribavirin alone or ribavirin plus pegylated interferon is also recommended.

Note: Both pros and cons should be taken into consideration before increasing the duration of treatment.

Once swallowed, sofosbuvir is absorbed (bio-available) in between 30 mins to 2 hours with a binding affinity of 61-65% with viral cells. It is generally metabolized in the liver and after its activities, more than 50% of the drug is excreted from the body in between 40 minutes to 27 hours.

When should Hepcinat 400 (Sofosbuvir) be avoided or used cautiously?

Interactions with other drugs:

If patients were taking other drugs before or along with sofosbuvir,

• •  The efficacy gets comprised

• •  Dosages need to be modified

• •  Shows a higher rate of side-effects

Other warning signs:

If patients are suffering from or had,

• •  History of Hepatitis B viral infection before taking sofosbuvir.

• •  Liver transplant before the initiation of dosage

• •  Complications in the liver other than HCV infection

• •  Heart problems

• •  Kidney disease or undergoing dialysis

• •  HIV infection

• •  Other severe medical condition

Issues during childbirth if patients,

• •  Are pregnant or planning to get pregnant

• •  Are male and your partner is planning to get pregnant

• •  Are breastfeeding or planning to breastfeed

Side-effects of Qurled 400 mg (Sofosbuvir):

Sofosbuvir has a reasonable safety profile with minimal side-effects. Due to its safety profile, it has a therapeutic advantage over other anti-HCV agents like the absence of low red blood cell (RBC) count (anemia) and neuropsychiatric effects.

Serious side-effects: Slow heart rate (bradycardia)

Side-effects in combination with ribavirin:

• •  Headache

• •  Tiredness (Fatigue)

Side-effects in combination with ribavirin and pegylated interferon:

• •  Lack of sleep (Insomnia)

• •  Nausea

• •  Tiredness (Fatigue)

• •  Headache

Uncommon side-effects:

• •  Pain in the muscles (Myalgia)

• •  Physical weakness (Asthenia)

• •  Skin itchiness (Pruritis)

• •  Diarrhea

• •  Severe rashes on the skin

• •  Fever

• •  Chills

• •  Low consumption of diet

Note: These are not all possible side-effects of Qurdac 400 mg (Sofosbuvir), please ask your doctor for more information regarding the same.