L-Aprakast 10000 IU

L-Aprakast

Composition: L Asparaginase 10000 IU for IM and IV administration

Therapeutic Class – Antineoplastic agent

What is L-Aprakast?

L-Aprakast is an enzyme used as an anticancer medicine that blocks the cancer processes of growth and division.

It is the targeted therapy drug that kills the viable cells without harming the normal cells

It is used to achieve complete remission in adults and pediatric patients.

Uses of L-Aprakast –

• Lymphoblastic Leukemia (acute)

• Lymphoblastic lymphoma

How does L-Aprakast Work?

• Break down the L-asparagine enzyme

• Cancer cell starvation

• Apoptosis and cell death

Common Side Effects of L-Aparakast

• Increases infection risks

• Blood clots

• Diarrhea

• Weight loss

• Loss of appetite

• High albumun levels, bilirubin levels

• Oedema

• Lowered blood pressure

• Abdominal pain

Serious Side-Effects

• Pancreatic bleeding

• Thromboembolism- clots and strokes

• Bone marrow suppression – thrombocytopenia

• Shortness of breath

Toxicities

• Hepatotoxicity

• Thrombosis and bleeding

• Pancreatitis

Contraindications

• Not to be used in patients with prior hypersensitivity to the drug or its excipients.

• Breastfeeding mothers

• Pregnant women

Precautions

To be used cautiously in patients with

• Heart disease

• Low blood count

• Liver disease

• Pancreatitis

Warnings

To be used under medical supervision only, do not mix dextrose-containing solutions.

Important safety and monitoring information

Regular monitoring is required for liver functions, pancreatic enzymes, blood coagulants, and sugar levels.

Storage:

Store at 2-8 degrees Celsius (refrigerator), protected from light.

Reconstituted solution to be used immediately.