Cabozer 40mg Tablet

Cabozer 40mg Tablet

Composition: Cabozantinib S-Malate IP - 40mg

Therapeutic Class –Antineoplastic

What is Cabozer?

Cabozer is a targeted therapy anticancer drug used for solid tumors.

Uses of Cabozer -

• Advanced Renal Carcinoma

• Hepatocellular Carcinoma

• Medullary Thyroid Carcinoma

• Differentiated Thyroid cancer

How does Cabozer Work?

• Carbozer inhibits Multiple Receptor tyrosine kinases, which are signal inducers for cell division and proliferation.

• It inhibits several enzymes – EGFR ,HER2, VEGFR,ALK, MET which are over-expressed in liver ,breast , blood and lungs.

• Slows tumor growth

• Inhibits blood supply to the tumor

• Reduces the spread of the tumor

Common Side Effects of Cabozer

Nausea, vomiting, fatigue, high blood pressure, mucosal ulcers, hand-foot syndrome, loss of appetite.

Serious Side-Effects

• Severe bleeding or hemorrhage

• Elevation of the liver enzymes

• GIT perforation- hole in the GIT wall

• Cardiovascular risk – clots and strokes

Contraindications

• Not to be used in patients with prior hypersensitivity to the drug or its excipients.

• Breastfeeding mothers

• Pregnant women

Precautions

To be cautiously used in patients with –

• Bleeding disorder

• Cardiovascular diseases

• Hepatic, renal impairment

• Recent surgery or wound

• Disorders of the stomach

Toxicities

• Hepatotoxicity

• Gastrointestinal Toxicity

• Hematological toxicity

• Cardiovascular toxicity

Warnings

Prescription drug to be used under medical supervision

Important safety and monitoring information

Cabozer requires regular monitoring for hematological functions, blood pressure, liver functions, ECG, wound healing or dental or oral health